Development of DDS for mRNA therapeutics: Polyplex nanomicelle
نویسندگان
چکیده
منابع مشابه
Polyplex nanomicelle promotes hydrodynamic gene introduction to skeletal muscle.
Skeletal muscle is an interesting target for gene therapy. To achieve effective gene introduction in skeletal muscle, a hydrodynamic approach by intravenous injection of plasmid DNA (pDNA) with transient isolation of the limb has attracted attention. In this study, we demonstrated that polyplex nanomicelle, composed of poly(ethyleneglycol) (PEG)-block-polycation and pDNA, showed excellent capac...
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 2020
ISSN: 0913-5006,1881-2732
DOI: 10.2745/dds.35.27